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Synlett 1996; 1996(10): 969-970
DOI: 10.1055/s-1996-5655
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Synthesis of Tris-Bridged Cyclic Hexapeptide Containing Hydrophilic Amino Acid Residues as an Active Site of Lipase

Hiroshi Uchida, Kazuo Achiwa*
  • *School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Schizuoka 422, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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Tris-bridged cyclic hexapeptide containing hydrophilic amino acid residues as an active site of lipase was synthesized from the piperazin-2-one derivatives which were obtained by treatment of the corresponding substituted dipeptides with p-toluenesulfonic acid or trifluoroacetic acid in toluene.

cyclic peptide - ethylene-bridge - piperazin-2-one - lipase