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Synlett 1996; 1996(12): 1176-1178
DOI: 10.1055/s-1996-5708
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Baker’s Yeast Mediated Biohydrogenation of 2-Substituted Allyl Alcohols: Synthesis of Enantiomerically Pure (2S)-3-Benzyloxy-2-methyl-1-propanol

Patrizia Ferraboschi, Shahrzad Reza Elahi, Elisa Verza, Francesco Meroni Rivolta, Enzo Santaniello*
  • *Dipartimento di Chimica e Biochimica Medica, Università degli Studi di Milano - Via Saldini, 50 - 20133 Milano, Italy, Fax +39(2)2361407
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Publication History

Publication Date:
31 December 2000 (online)

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The baker’s yeast biohydrogenation of the 2-substituted allyl alcohol 2a, in turn prepared from dihydroxyacetone dimer (DHAD) 7a afforded the enantiomerically pure (2S)-3-benzyloxy-2-methyl-1-propanol 1a (>98% ee).

(2S)-3-Benzyloxy-2-methyl-1-propanol - biohydrogenation - baker’s yeast - dihydroxyacetone dimer