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Synlett 1997; 1997(11): 1243-1244
DOI: 10.1055/s-1997-1007
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A Simple Approach to β-Amino Acids by Acylation of Arenes with N-Acyl Aspartic Anhydrides

Axel G. Griesbeck* , Heike Heckroth
  • *Department of Organic Chemistry, Universität zu Köln, Greinstr. 4, D-50939 Köln, Germany, Fax 0049 221 470 5057
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Publication Date:
31 December 2000 (online)

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Friedel-Crafts acylation of arenes (benzene, toluene, o-xylene) with N-protected (Bz, Ac, Ac-Bn, Ts, Tfac, N,N-Pht) aspartic anhydrides (1a-1f) resulted in mixtures of α- and β-amino acids. The β/α-selectivity could be optimized for alkylated arenes (toluene, xylene) and the N-Ac, N-Bn protected 1c.

β-amino acids - Friedel-Crafts acylation - aluminum chloride