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Synlett 1997; 1997(11): 1269-1270
DOI: 10.1055/s-1997-1008
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Condensation of Dimethyl-3-methylglutaconate with α-Aminoaldehydes: A Straightforward Synthesis of New 2-Substituted Statines

Nathalie Piveteau, Patrick Audin* , Joëlle Paris
  • *Laboratoire de Chimie Thérapeutique, ISPB, Faculté de Pharmacie, 8 Avenue Rockefeller 69373 LYON Cedex 08, Fax: (33) 04 78 77 71 58; Email: audin@univ-lyon1.fr
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Publication History

Publication Date:
31 December 2000 (online)

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Dimethyl-3-methylglutaconate reacts with chiral α-aminoaldehydes under basic conditions to afford 2-substituted γ-amino-β-hydroxyesters (statine derivatives). The anti derivatives were obtained in a diastereoselective manner.

aldolisation - aminoaldehydes - diastereoselectivity - dimethyl-3-methylglutaconate - statines