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Synlett 1997; 1997(12): 1371-1374
DOI: 10.1055/s-1997-1059
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Early Transition Metal Induced Intramolecular Cocyclisation/Elaboration Reactions Using a Cleavable Silicon Linker

Gareth D. Probert1 , Ross Harding1 , Richard J. Whitby2 , Steven J. Coote3
  • 1Department of Chemistry, Southampton University, Southampton, HANTS, SO17 1BJ, U.K.
  • 2Department of Chemistry, Southampton University, Southampton, HANTS, SO17 1BJ, U.K.; E-mail: rjw1@soton.ac.uk
  • 3Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
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Publikationsdatum:
31. Dezember 2000 (online)

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1,6- and 1,7-dienes and -enynes incorporating a silicon-oxygen or silicon-nitrogen link are co-cyclised with zirconocene(1-butene) or diisopropoxytitanium(propene) to give metallabicycles. Further elaboration followed by cleavage of the silicon-carbon bond using Tamao oxidation affords a wide variety of organic products.

zirconium - silicon - cocyclisation - cleavable linker - Tamao oxidation