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Synthesis 1997; 1997(2): 191-194
DOI: 10.1055/s-1997-1167
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Synthesis of Enantiomerically Pure Heterocycles: Access to Hydroxylated Piperidines from a Sugar Lactone

Christine Thomassigny, Khalil Bennis, Jacques Gelas*
  • *Ecole Nationale Supérieure de Chimie de Clermont-Ferrand, B.P. 187, 63174 Aubière Cedex, France, Fax +33(473)73407095
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Publikationsdatum:
31. Dezember 2000 (online)

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A protected hydroxylated piperidine 7 and its bicyclo- and substituted diastereoisomers 12 and 13, respectively, have been synthesizes from α-D-isosaccharino-1,4-lactone (3), in two very short sequences.

α-D-isosaccharino-1,4-lactone - inhibitors of glycosidase - polyhydroxylated piperidine - anhydro - primary amine