Download PDF
Synthesis 1997; 1997(2): 195-201
DOI: 10.1055/s-1997-1168
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

New DBU (1,8-Diazabicyclo[5.4.0]undec-7-ene) Assisted One-Pot Synthesis of 2,8-Disubstituted 4H-1-Benzopyran-4-ones

Carlo Riva* , Carlo De Toma, Leandro Donadel, Carlo Boi, Renzo Pennini, Gianni Motta, Amedeo Leonardi
  • *Pharmaceutical R. & D. Division, Recordati S.p.A., Via Civitali 1, I-20148, Milano, Italy, Fax +39(2)48709017
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

2-Hydroxy-3-(alkoxycarbonyl or prop-1-enyl)phenyl alkyl ketones are easily converted into 2,8-disubstituted (3-methyl)-4H-1-benzopyran-4-ones through a new DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) assisted one-pot synthesis, by reaction with aroyl or alkanoyl chlorides or anhydrides. The method is simple, mild and convenient as compared to the existing multistep procedures.

1,8-diazabicyclo[5.4.0]undec-7-ene - 4-oxo-4H-1-benzopyran-8-carboxylates - one-pot synthesis - 2,8-distubstituted-4H-1-benzopyran-4-ones - 2-hydroxy-3-(1-oxoalkyl)-benzoates