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Synthesis 1997; 1997(3): 297-300
DOI: 10.1055/s-1997-1176
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Preparation of Spiro[1-benzazepine-4,1'-cyclohexane] Derivatives from 1H-1-Benzazepine-2,5(3H,4H)-diones and Mannich Bases

Andreas Link, Conrad Kunick*
  • *Universität Hamburg, Institut für Pharmazie, Bundesstraße 45, D-20146 Hamburg, Germany, Fax +49(40)41232893
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Publication Date:
31 December 2000 (online)

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3'-Aroyl-4'-aryl-4'-hydroxyspirol[1-benzazepine-4,1'-cyclohexane]-2,5(1H,3H)-diones were synthesized by reaction of 1H-benzazepine-2,5(3H,4H)-diones with aromatic ketone Mannich bases. The new compounds exhibited in vitro antitumor activity on distinct cell lines.

tandem Michael-aldol reaction - 1-benzazepine-2,5-diones - Mannich bases - cyclohexanols - spiro compounds