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Synthesis 1997; 1997(4): 415-416
DOI: 10.1055/s-1997-1205
short paper
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A Convenient Synthesis of Phenyl α-(Benzyloxycarbonylamino)benzylphosphinic Acids

Qing Dai* , Ruyu Chen
  • *Institute and State’s Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, People’s Republic of China, Fax +86(22)3503438; E-mail: rychen@public.tpt.tj.cn
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Publication Date:
31 December 2000 (online)

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A series of phenyl α-(benzyloxycarbonylamino)benzylphosphinic acids are prepared from benzyl carbamate, substituted benzaldehydes and phenyldichlorophosphine in acetyl chloride via the corresponding phosphinic chloride 4. The reaction proceeds smoothly at room temperature and affords the title compounds in good yields.

phosphinic acid - phosphinic chloride - condensation reaction - phosphinopeptide - diastereoisomers