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Synthesis 1997; 1997(5): 518-520
DOI: 10.1055/s-1997-1220
DOI: 10.1055/s-1997-1220
short paper
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A Convenient Laboratory Preparation of Propargylthiol and Its Derivatives
Further Information
Publication History
Publication Date:
31 December 2000 (online)
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Reduction of propargyl S-thioacetate, followed by elimination of excess hydride and acidification, constitutes a practical alternative for the preparation of propargylthiol (as a solution of easily determined concentration) or of its derivatives (by trapping the intermediate thiolate with a suitable electrophile).
Propargylthiol and its derivatives are easily obtained through the hydride-mediated reduction of propargyl thioacetate