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Synthesis 1997; 1997(5): 549-552
DOI: 10.1055/s-1997-1226
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Lipase-Mediated Resolution of Indene Bromohydrin

Yoshio Igarashi1 , Shinya Otsutomo2 , Masayuki Harada2 , Shigeru Nakano2 , Shoji Watanabe3
  • 1Department of Research and Development, Ichikawa Gohsei Chemical Co. Ltd., Shimokawa, Izumi-machi, Iwaki, Fukushima 971, Japan, Fax +81(24)2561744
  • 2Department of Research and Development, Ichikawa Gohsei Chemical Co. Ltd., Shimokawa, Izumi-machi, Iwaki, Fukushima 971, Japan
  • 3Department of Applied Chemistry, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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Lipase-mediated resolution of indene bromohydrin was examined, and we have found that immobilized CAL (Candida antarctica lipase SP525 immobilized on acurrell) was an efficient biocatalyst to resolve a readily available racemic indene bromohydrin (±)-1. Enantiomerically enriched (1R,2R)-2-bromoindan-1-ol (-)-1 and its (1S,2S-acetate) (+)-2 were obtained by this method.

lipase-mediated kinetic resolution - indene bromohydrin - immobilized Candida antarctica lipase - cis-1-aminoindan-2-ol