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Synthesis 1997; 1997(8): 861-862
DOI: 10.1055/s-1997-1296
short paper
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Synthesis of Highly Functionalized 1,3-Oxazoles

Fillmore Freeman* , Tao Chen, Johannes B. van der Linden
  • *Department of Chemistry, University of California, Irvine, California 92697-2025, E-mail: FFREEMAN@UCI.EDU
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Publikationsdatum:
31. Dezember 2000 (online)

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A convenient one-pot method for the preparation of 2-substituted 5-amino-4-cyano-1,3-oxazoles from carboxylic acids and aminopropanedinitrile p-toluenesulfonate (AMNT, aminomalononitrile tosylate, 1) is reported.

1,3-oxazoles - aminomalononitrile tosylate (AMNT) - carboxylic acids - anti-HIV/AIDS - anti-cancer - dicyclohexylcarbodiimide (DCC)