Synthesis of the Bifunctional Chelating Agent 6-(4-Aminobenzyl)-1,4,8,11-tetra-azacyclotetradecan-N,N',N'',N'''-tetraacetic Acid (H2NBn-TETA)

P. Moreau; M. Tinkl; M. Tsukazaki; P. S. Bury; E. J. Griffen; V. Snieckus; R. B. Maharajh; C. S. Kwok; V. V. Somayaji; Z. Peng; T. R. Sykes; A. A. Noujaim

doi:10.1055/s-1997-1314

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Synthesis 1997; 1997(9): 1010-1012
DOI: 10.1055/s-1997-1314

short paper

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Synthesis of the Bifunctional Chelating Agent 6-(4-Aminobenzyl)-1,4,8,11-tetra-azacyclotetradecan-N,N',N'',N'''-tetraacetic Acid (H₂NBn-TETA)

P. Moreau^*

^*The Guelph-Waterloo Center for Graduate Work in Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada

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Publication Date:
31 December 2000 (online)

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An improved, five-step synthesis (7% overall yield) of 6-(4-aminobenzyl)-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid (H₂NBn-TETA, 6), an azamacrocyclic ligand used as a radionuclide carrier in cancer chemotherapy, is reported and its complete characterization and purification is for the first time described.

azamacrocycles