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Synthesis 1997; 1997(10): 1189-1194
DOI: 10.1055/s-1997-1335
DOI: 10.1055/s-1997-1335
paper
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A Practical Synthesis of Ureas from Phenyl Carbamates
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synthesis/199710/lookinside/thumbnails/10.1055-s-1997-1335-1.jpg)
Using DMSO as solvent, a mild and efficient procedure for the synthesis of unsymmetrical N,N'-disubstituted ureas from phenyl carbamates is described. The carbamates are treated with a stoichiometric amount of amine at ambient temperature, generating the ureas in high yield and high purity. The reaction is mild, fast, and easily scaled up.
phenyl carbamates - unsymmetrical ureas - mild conditions - DMSO as solvent