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Synthesis 1997; 1997(11): 1240-1242
DOI: 10.1055/s-1997-1355
short paper
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Synthesis of Polyunsaturated β-Oxa Fatty Acids via Rhodium Mediated Carbenoid Insertion

Michael J. Pitt1 , Christopher J. Easton2 , Christopher J. Moody3 , Antonio Ferrante4 , Alfred Poulos4 , Deborah A. Rathjen5
  • 1Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
  • 2Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia, E-mail: easton@rsc.anu.edu.au
  • 3Department of Chemistry, University of Exeter, Exeter EX4 4QD, UK
  • 4Adelaide Medical Centre for Women and Children, North Adelaide SA 5006, Australia
  • 5Adelaide Medical Centre for Women and Children, North Adelaide SA 5006, Australia; Peptide Technology (Australia) Ltd, North Ryde NSW 2113, Australia
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Publication History

Publication Date:
31 December 2000 (online)

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Polyunsaturated β-oxa fatty acids 1 are readily obtained from naturally derived polyunsaturated fatty alcohols 2 via rhodium(II) acetate-catalysed reaction with tert-butyl diazoacetate 3, followed by ester cleavage.

fatty acids - β-oxidation - diazocarbonyl - rhodium - insertion

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