Synthesis 1997; 1997(12): 1475-1480
DOI: 10.1055/s-1997-1375
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New Synthesis of 2,6-Diaryl-4-oxo-3,7-dioxabicyclo[3.3.0]octanes: Synthesis of (±)-Styraxin

Shin-ichi Yoshida, Tsuyoshi Ogiku, Hiroshi Ohmizu* , Tameo Iwasaki
  • *Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89, Kashima, Yodogawa, Osaka 532, Japan, Fax +81(6)3002679; E-mail: h-ohmizu@tanabe.co.jp
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Publication History

Publication Date:
31 December 2000 (online)

An efficient method for the stereocontrolled synthesis of the unsymmetrically substituted 4-oxofurofuran lignan 1 has been developed based on a stereocontrolled aldol reaction of the succinic anhydride derivative 20 with an aromatic aldehyde employing (±)-styraxin as a representative example.