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Synthesis 1997; 1997(12): 1387-1388
DOI: 10.1055/s-1997-1383
short paper
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Oxidation of N-Heterocycles by H2O2 Catalyzed by a Mn-Porphyrin: An Easy Access to N-Oxides Under Mild Conditions

A. Thellend1 , P. Battioni2 , W. Sanderson3 , D. Mansuy2
  • 1Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (URA 400), Université René Descartes, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France, Fax +33(1)44277150; E-mail: thellend@ccr.jussieu.fr
  • 2Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (URA 400), Université René Descartes, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France
  • 3Solvay Interox, R & D Widnes Laboratories, Widnes, Cheshire, WA8 OFE, England
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Publication History

Publication Date:
31 December 2000 (online)

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A variety of N-heteroaromatic compounds were converted into their corresponding N-oxides with good yields and with high chemoselectivity in the presence of hydrogen peroxide as oxygen donor and a catalytic amount of Mn-porphyrin. The scope and limitation of this method are discussed.

heteroaromatic N-oxides - oxidation - hydrogen peroxide - Mn-porphyrin