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Synthesis 1997; 1997(6): 623-624
DOI: 10.1055/s-1997-1396
short paper
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An Improved Stereoselective Synthesis of 5-Acyl-2-amino-4-aryl-3-cyano-4,5-dihydrothiophenes

Aleksandr V. Samet* , Anatolij M. Shestopalov, Vladimir N. Nesterov, Victor V. Semenov
  • *N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913 Moscow, Russian Federation, Fax +7(095)1355328
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Publication Date:
31 December 2000 (online)

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Sulfonium ylides generated from precursor bromides 2 react readily with arylidenecyanothioacetamides 1 to afford the title compounds with trans-configuration.

arylidenecyanothioacetamides - sulfonium ylide - trans-2-amino-3-cyano-4,5-dihydrothiophenes - stereoselective cyclization - 3-component condensation