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Synthesis 1997; 1997(1): 32-34
DOI: 10.1055/s-1997-1518
short paper
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An Enantioselective Synthesis of Cyclopentyl-L-Aspartic Acid Amenable to Large Scale

Neil Moss* , Jean-Marie Ferland, Sylvie Goulet, Ingrid Guse, Eric Malenfant, Louis Plamondon, Raymond Plante, Robert Déziel
  • *Bio-Méga/Boehringer Ingelheim Research Inc., 2100 Cunard, Laval, Quebec, Canada, H7S 2G5, Fax +1(514)6828434
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Publication Date:
31 December 2000 (online)

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A new enantioselective synthesis of cyclopentyl-L-aspartic acid[(S)-αamino-1-(carboxy)cyclopentaneacetic acid] (1) and its N-Boc derivative 2 has been developed. This synthesis is amenable to kilogram scale preparation and avoids low temperature reactions and column chromatography.

enantioselective synthesis - cyclopentyl-L-aspartic acid - Strecker synthesis - no chromatography