Synthesis of Oxorhenium (V) and Oxotechnetium (V) Complexes as Inhibitors of Ribonucleases and for the Generation of Catalytic Antibodies

Since the discovery of catalytic antibodies in the mid 1980s, the generation of programmable catalysts for use in chemistry and biomedicine has come a step closer. In one of our latest efforts, we are attempting to generate antibody catalysts that will hydrolyze RNA and serve general use in a number of fields including molecular and cellular biology and medicine. We have synthesized a number of oxotechnetium (V) and oxorhenium (V) complexes as stable mimics of the pentaoxyphosphorane intermediate generated during RNA hydrolysis and have studied their ability to inhibit ribonucleases. In parallel, these complexes have been developed, as haptens, to generate antibody catalysts for phosphodiester hydrolysis.

catalytic antibody - ribonuclease - ribonucleoside metallocycles - haptens