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Synlett 1997; 1997(6): 725-727
DOI: 10.1055/s-1997-3248
DOI: 10.1055/s-1997-3248
letter
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A Tandem Amino-Cope Rearrangement/Enamine Alkylation Reaction
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199706/lookinside/thumbnails/10.1055-s-1997-3248-1.jpg)
Thermally induced [3,3]-sigmatropic rearrangement of 3-amino-1,5-diene substrates occurs to give the corresponding enamine products in high yield and with excellent trans:cis enamine selectivity. The enamine produced during the amino-Cope rearrangement has been directly derivatized, representing the first report of a tandem amino-Cope rearrangement/enamine alkylation reaction. The potential of this novel synthetic strategy is outlined.
sigmatropic rearrangement - enamine alkylation