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Synlett 1997; 1997(6): 650-652
DOI: 10.1055/s-1997-3259
DOI: 10.1055/s-1997-3259
letter
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Design and Synthesis of b-Series Ganglioside Mimetics
Further Information
Publication History
Publication Date:
31 December 2000 (online)
Artificial glycolipids composed from phosphatidyl-ethanolamine and one or two sets of sialylα(2-8)sialoside were designed and prepared as mimetics of b-series gangliosides, GD3 and GQlb, which have respectively cholinergic differentiation potency in murine neuroblastoma cells and neutritogenic effect in human neuroblastoma cell line.
GQ1b - GD3 - ganglioside - mimic