Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml
Synlett 1997; 1997(6): 707-709
DOI: 10.1055/s-1997-3270
DOI: 10.1055/s-1997-3270
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Preparation of a Promising Cyclobutanone Chiral Building Block: Its Stereochemistry and Utilization
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199706/lookinside/thumbnails/10.1055-s-1997-3270-1.jpg)
A cyclobutanone possessing a bicyclo[2.2.1]heptene framework {endo-tricyclo[4.2.1.02,5]non-7-en-3-one} has been prepared in both enantiomeric forms employing lipase-mediated kinetic resolution as the key step. To determine the absolute configuration, as well as to demonstrate the synthetic potential, both enantiomers of the cyclobutanone obtained have been transformed enantioconvergently into the key intermediate of the sequiterpene (+)-β-santalene and the iridoid monoterpene (-)-boschnialactone.
chiral building block - endo-tricyclo[4.2.1.02,5]non-7-en-3-one - iridoid monoterpene - lipase-mediated kinetic resolution - enantioconvergent synthesis