Synthesis 1997; 1997(3): 281-283
DOI: 10.1055/s-1997-4463
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New Efficient Synthesis of 3-Nitropyridine and Substituted Derivatives

Jan M. Bakke* , Eli Ranes
  • *Organic Chemistry Laboratories, The Norwegian University of Science and Technology, Sem Sælandsvei 8, N-7034 Trondheim, Norway, Fax +47(7359)4256; E-mail bakke@kjemi.unit.no
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Pyridine and pyridine derivatives have been nitrated in the β-position by reaction with N2O5 or NO2 ⋅ BF4 in MeNO2, THF or MeCN to form the N-nitropyridinium salt. This was then reacted with an aqueous solution of a nucleophile to give the β-nitro compound in moderate to good yield.