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Synlett 1997; 1997(SI): 531-532
DOI: 10.1055/s-1997-6113
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Facile KF/Alumina Mediated Synthesis of α-Heterosubstituted Weinreb Amides

Marcus A. Tius* , Jakob Busch-Petersen
  • *Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, HI 96822, U.S.A., Fax: (808) 956-5908; E-mail: tius@gold.chem.hawaii.edu
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Publication Date:
31 December 2000 (online)

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Anhydrous KF/alumina in dipolar aprotic solvents was found to be an effective promoter in the synthesis of α-heterosubstituted Weinreb amide prepared from 2-chloro-N-methoxy-N-methylacetamide. This method is highly yielding, even for weak nucleophiles, and requires no aqueous workup.

Weinreb amides - potassium fluoride - alumina - sonication