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Synlett 1997; 1997(SI): 488-490
DOI: 10.1055/s-1997-6118
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Convergent Parallel Synthesis

Carmen M. Baldino, David S. Casebier, Justin Caserta, Gregory Slobodkin, Cheng Tu, David L. Coffen*
  • *ArQule, Inc., 200 Boston Avenue, Medford, MA 02155, USA
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Publikationsdatum:
31. Dezember 2000 (online)

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The considerable gain in efficiency achievable by introducing the principle of convergence into automated parallel synthesis is illustrated with a seven-step synthesis of a sixteen-hundred-compound array of potential serine protease inhibitors, conducted on a 50 μmole scale (ca. 20 mg. of each compound).

combinatorial chemistry - α-keto amide