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Synlett 1997; 1997(SI): 529-530
DOI: 10.1055/s-1997-6139
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Asymmetric Amino Acid Synthesis: Mitsunobu Reaction on Chiral Cyanohydrins

Carl P. Decicco* , Paul Grover
  • *Chemical and Physical Sciences, The DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington, DE, USA, 19880-0500
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Publication Date:
31 December 2000 (online)

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BOC(SES)NH was reacted with chiral cyanohydrins using the Mitsunobu reaction to give good yields of protected α-aminonitriles, which were converted to chiral amino and imino acids.

cyanohydrin - amino acid - asymmetric synthesis - Mitsunobu reaction