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Synlett 1997; 1997(SI): 467-468
DOI: 10.1055/s-1997-6141
DOI: 10.1055/s-1997-6141
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Asymmetric Hydrogenation of Cyclic α,β-Unsaturated Ketones to Chiral Allylic Alcohols
Further Information
Publication History
Publication Date:
31 December 2000 (online)
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The Ru(II)-BINAP-1,2-diphenylethylenediamine combined catalyst system effects asymmetric hydrogenation of certain cyclic enones in 2-propanol containing KOH with a substrate/catalyst molar ratio of 250 to 2500. The hydrogenation occurs selectively at the C=O function with excellent enantio- or diastereoselectivity.
asymmetric hydrogenation - BINAP - chiral allylic alcohol - chiral - 1,2-diamine - α,β-unsaturated ketone