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Synlett 1997; 1997(SI): 463-466
DOI: 10.1055/s-1997-6145
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Stable Diaqua Palladium(II) Complexes of BINAP and Tol-BINAP as Highly Efficient Catalysts for Asymmetric Aldol Reactions

Mikiko Sodeoka1 , Ryosuke Tokunoh2 , Futoshi Miyazaki2 , Emiko Hagiwara3 , Masakatsu Shibasaki4
  • 1Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan, Fax 81-3-5684-5206; Sagami Chemical Research Center, Nishi-Ohnuma, Sagamihara, Kanagawa 229, Japan, Fax 81-427-49-7631; e-mail sodeoka@ppp.bekkoame.or.jp
  • 2Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
  • 3Sagami Chemical Research Center, Nishi-Ohnuma, Sagamihara, Kanagawa 229, Japan
  • 4Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan, Fax 81-3-5684-5206; e-mail mshibasa@mol.f.u-tokyo.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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The novel chiral diaqua palladium(II) complexes of (R)-BINAP 9a and (R)-Tol-BINAP 9b were prepared in good yield, and their structures were determined by X-ray crystallography. These air- and moisture-stable complexes were found to be excellent catalysts for the asymmetric aldol reaction, and up to 89% ee of asymmetric induction was achieved using these catalysts.

asymmetric aldol reaction - diaqua palladium complex - chiral catalyst