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Synlett 1997; 1997(1): 66-68
DOI: 10.1055/s-1997-705
DOI: 10.1055/s-1997-705
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Stereoselective Methodology for 1-Aryl-1-alkyl Epoxides via Chromium Tricarbonyl Complexes
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Publication Date:
22 March 2004 (online)
Treatment of (1RS,SSR)-(1-phenylsulfinyl-2-valeryl benzene) chromium tricarbonyl 2 with a sulfur ylide results in a highly diastereoselective epoxide formation (d.s.>96:4). Regioselective opening of the epoxide, employing an in situ trapping protocol, allows the synthesis of a highly functionalised, diastereomerically pure benzylic alcohol.
chromium tricarbonyl - stereoselective - epoxide formation