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Synlett 1997; 1997(2): 221-222
DOI: 10.1055/s-1997-744
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A Facile Synthesis of (R)-4-Amino-3-hydroxybutanoic Acid (GABOB) from 3-Hydroxypyridine

Hideki Sakagami, Takashi Kamikubo, Kunio Ogasawara*
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-77, Japan, Fax +81-22-217-6845; e-mail c21799@cctu.cc.tohoku.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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(R)-4-Amino-3-hydroxybutanoic acid (GABOB) has been synthesized facilely from 3-hydroxypyridine via 1-carbobenzoxy-1,2,3,4-tetrahydro-3-hydroxypyridine employing lipase-mediated kinetic resolution.

3-hydroxypyridine - reduction - N-carbobenzoxy-1,2,3,4-tetrahydro-3-hydroxypyridine - lipase-mediated resolution - GABOB