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Synlett 1997; 1997(3): 257-260
DOI: 10.1055/s-1997-765
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One-Pot Synthesis of Tetra- and Pentasaccharides from Monomeric Building Blocks Using the Principles of Orthogonality and Reactivity Tuning

Man-Ki Cheung, Nina L. Douglas, Berthold Hinzen, Steven V. Ley* , Xavier Pannecoucke
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
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Publication Date:
31 December 2000 (online)

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Tuning the reactivity of glycosyl donors, by selective introduction of different protecting and leaving groups, in conjunction with the principle of orthogonal activation enabled highly efficient oligosaccharide synthesis. One-pot sequential glycosidation of four or five components gave tetrasaccharides and pentasaccharides respectively.

reactivity tuning - one-pot synthesis - orthogonality - tetrasaccharide