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Synlett 1997; 1997(3): 291-292
DOI: 10.1055/s-1997-767
DOI: 10.1055/s-1997-767
letter
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Asymmetric C-C Bond Forming Reactions by Chiral Crown Catalysts; Darzens Condensation and Nitroalkane Addition to the Double Bond
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199703/lookinside/thumbnails/10.1055-s-1997-767-1.jpg)
A new, efficient crown ether 1 anellated to a sugar derivative has been prepared which shows significant asymmetric induction as phase transfer catalyst in the Michael addition of 2-nitropropane to chalcone (60% ee for the S antipode) and in the Darzens condensation of phenacyl chloride and benzaldehyde (64% ee), simultaneously changing the PT process from solid-liquid to liquid-liquid phase.
chiral crown ethers - asymmetric Michael addition - Darzens condensation