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Synlett 1997; 1997(3): 263-264
DOI: 10.1055/s-1997-772
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A Versatile Route to 2-Arylmethyl-1,2,4-oxadiazolidine-3,5-diones via Regiospecific Alkylation of 1,2,4-Oxadiazolidine-3,5-dione

Barrie C.C. Cantello, Susan C. Connor1 , David K. Dean2 , Richard M. Hindley
  • 1Department of Analytical Sciences, SmithKline Beecham Pharmaceuticals, Great Burgh, Epsom, Surrey, KT18 5XQ, UK
  • 2Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Great Burgh, Epsom, Surrey, KT18 5XQ, UK; E-mail: David_K_Dean@sbphrd.com
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Publication History

Publication Date:
31 December 2000 (online)

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2-Arylmethyl-1,2,4-oxadiazolidine-3,5-diones can be prepared in a single step by the regiospecific alkylation of 1,2,4-oxadiazolidine-3,5-dione with substituted benzyl halides.

bioisostere - insulin sensitiser - 1,2,4-oxadiazolidine-3,5-dione - regiospecific alkylation - thiazolidinedione