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Synlett 1997; 1997(3): 273-274
DOI: 10.1055/s-1997-779
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A Practical Method for Asymmetric Borane Reduction of Prochiral Ketones Using Chiral Amino Alcohols and Trimethyl Borate

Moriyasu Masui1 , Takayuki Shioiri2
  • 1Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Koka-gun, Shiga 520-34, Japan
  • 2Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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A new method for the asymmetric borane reduction with reagents prepared in situ from chiral amino alcohols and trimethyl borate is described.

asymmetric reduction - α-pinene - trimethyl borate - chiral alcohol - nitrogen containing ketone