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Synlett 1997; 1997(3): 298-300
DOI: 10.1055/s-1997-785
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Synthesis of Functionalized Heteroaromatics: Application to Formal Total Synthesis of Camptothecin

Naoko Murata1 , Takumichi Sugihara, Yoshinori Kondo, Takao Sakamoto2
  • 1Faculty of Pharmaceutical Science, Tohoku University, Aobayama, Sendai 980-77, Japan, Fax +81-22-217-6864
  • 2Faculty of Pharmaceutical Science, Tohoku University, Aobayama, Sendai 980-77, Japan, Fax +81-22-217-6864; E-mail sakamoto@phi.pharm.tohoku.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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The formal total synthesis of camptothecin was achieved via two types of lithiation reactions of pyridine derivatives and a Pd-catalyzed carbonylation of pyridylmethyl methanesulfonates.

camptothecin - lithiation - 2,6-dichloropyridine - the Pd-catalyzed cross-coupling reaction - the Pd-catalyzed carbonylation