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Synlett 1997; 1997(4): 363-364
DOI: 10.1055/s-1997-795
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Highly Diastereoselective Titanocene Catalysed Pinacol Couplings

Andreas Gansäuer*
  • *Institut für Organische Chemie, Georg-August-Universität, Tammannstr. 2, D-37077 Göttingen, Germany, Fax: +49-551-392944; e-mail agansae@gwdg.de
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Publikationsdatum:
31. Dezember 2000 (online)

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A novel catalytic pinacol coupling utilising 3 mol % of the readily available rac-ethylenebis(η5-tetrahydroindenyltitanium) dichloride (EBTHITiCl2) as catalyst is described. Diastereoselectivities are in excess of 95:5. The reaction conditions for the coupling of aromatic aldehydes are mild and tolerate a variety of functional groups interfering with dihydroxylation reactions and McMurry coupling reactions.

1,2-diol - diastereoselective catalysis - titanocene catalyst