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Synlett 1997; 1997(4): 378-380
DOI: 10.1055/s-1997-802
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2',3'-Cyclopropanated Nucleoside Dimers

Constantin G. Yannopoulos, Wen-Qiang Zhou, Peter Nower, Didier Peoc'h, Yogesh S. Sanghvi1 , George Just2
  • 1Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA 92008, USA
  • 2Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6
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Publication History

Publication Date:
31 December 2000 (online)

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Syntheses of three novel conformationally rigid dimers containing cyclopropyl -amide and -sulfonamide functionalities are described. Their incorporation into an oligonucleotide sequence resulted in considerable lowering of the Tm's in binding to their complementary RNA sequences.

antisense - 2',3'-cyclopropyl nucleosides - conformationally restricted nucleosides

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