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Synlett 1997; 1997(4): 381-383
DOI: 10.1055/s-1997-807
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A New Approach to Nine-Membered Enediyne Using a Palladium Catalyzed Cross-Coupling Reaction

Hiroshi Tanaka, Haruo Yamada, Akihisa Matsuda, Takashi Takahashi*
  • *Department of Chemical Engineering, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo 152, Japan
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Publication Date:
31 December 2000 (online)

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A synthetic approach to the 9-membered enediyne analogue 3 of neocarzinostatin chromophore by using a palladium-catalyzed cross coupling reaction and the conformational analyses of diynes 11 and 12 based on MM2 calculation are described.

neocarzinostatin-chr. - palladium catalyzed epoxide opening - zinc mediated 1,2-addition - palladium catalyzed cross-coupling - MM2 calculation