A New Approach to Nine-Membered Enediyne Using a Palladium Catalyzed Cross-Coupling Reaction

Hiroshi Tanaka; Haruo Yamada; Akihisa Matsuda; Takashi Takahashi

doi:10.1055/s-1997-807

Synlett 1997; 1997(4): 381-383
DOI: 10.1055/s-1997-807

letter

© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New Approach to Nine-Membered Enediyne Using a Palladium Catalyzed Cross-Coupling Reaction

Hiroshi Tanaka, Haruo Yamada, Akihisa Matsuda, Takashi Takahashi^*

^*Department of Chemical Engineering, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo 152, Japan

Abstract

PDF Download All articles of this category

A synthetic approach to the 9-membered enediyne analogue 3 of neocarzinostatin chromophore by using a palladium-catalyzed cross coupling reaction and the conformational analyses of diynes 11 and 12 based on MM2 calculation are described.

neocarzinostatin-chr. - palladium catalyzed epoxide opening - zinc mediated 1,2-addition - palladium catalyzed cross-coupling - MM2 calculation

PDF (222 kb)