Download PDF
Synlett 1997; 1997(Sup. I): 485-487
DOI: 10.1055/s-1997-940277
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Glucopyranose Spirohydantoins: Specific Inhibitors of Glycogen Phosphorylase

Carmen de la Fuente, Thomas M. Krülle, Kimberley A. Watson, Mary Gregoriou, Louise N. Johnson, Katerina E. Tsitsanou, Spyros E. Zographos, Nikos G. Oikonomakos, George W. J. Fleet*
  • *Dyson Perrins Laboratory, Oxford Centre for Molecular Sciences, South Parks Road, Oxford OX1 3QY, UK, E-mail george.fleet@dyson-perrins.oxford.ac.uk
Further Information

Publication History

Publication Date:
12 April 2006 (online)

  PDF Download  Permissions and Reprints All articles of this category

A short synthesis of the spirohydantoin of glucopyranose 1β [a potent and specific inhibitor of glycogen phosphorylase], together with its inactive anomer 1α, from a readily available heptonolactone is described; this is the first synthesis of a spirohydantoin of a pyranose in which the pyranose ring is formed after the hydantoin ring.

hydantocidin - glycogen phosphorylase - enzyme inhibition - hydantoin - lactone