Synlett 1997; 1997(10): 1193-1195
DOI: 10.1055/s-1997-989
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One Flask Preparation of Trifluoromethylated Amides from Ketones and Trifluoromethyltrimethylsilane via Ritter Reaction with Nitriles

Emily C. Tongco, G. K. Surya Prakash* , George A. Olah1
  • *Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, CA 90089-1661
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Trifluoromethylated amides are prepared in a simple one-flask reaction via the Ritter reaction of the corresponding trifluoromethylated silyl ethers, which themselves are readily obtained from the starting ketones and trifluoromethyltrimethylsilane. The yields are good to average.