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Synlett 1998; 1998(1): 49-50
DOI: 10.1055/s-1998-1561
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Enantioselective Palladium Catalyzed Allylic Amination Using New Chiral Pyridine-Phosphine Ligands

Thierry Constantieux* , Jean-Michel Brunel, Agnès Labande, Gérard Buono
  • *Ecole Nationale Supérieure de Synthèse, de Procédés et d'Ingénierie Chimiques d'Aix Marseille (E.N.S.S.P.I.C.A.M.), UMR 6516 CNRS, Av. Escadrille Normandie Niemen, 13397 Marseille, Cedex 20, France; Fax 04-91-02-77-76; E-mail: buono@spi-chim.u-3mrs.fr
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Publication History

Publication Date:
31 December 2000 (online)

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Asymmetric palladium catalyzed allylic amination of 5 with various amines has been studied using a new class of chiral pyridine-phosphine ligands. High enantioselectivities of up to 94% ee have been observed using benzylamine, veratrylamine or morpholine as nucleophiles.

allylic amination - palladium - enantioselective - pyridine-phosphine ligands - catalysis