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Synlett 1998; 1998(1): 37-38
DOI: 10.1055/s-1998-1580
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Stereoselective Syntheses of 2-Fluoro-2-methyl-3-hydroxypropionamides by Use of a Germyl Anion Species

Yasuo Yokoyama* , Kunio Mochida
  • *Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171, Japan
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Publication Date:
31 December 2000 (online)

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Effective syntheses of 2-fluoro-2-methyl-3-hydroxypropionamide derivatives by use of a germyl anion species are described. These reactions proceeded smoothly to give the desired compounds in good to excellent yields and stereoselectivities.

Et3GeNa - phenylthiopropionamide - 2-fluoro-2-methyl-3-hydroxypropionamide - high yield - anti-selective