Heck Reaction versus Free Radical Reaction for the Synthesis of Spiro[indoline-2,4′-piperidines]

Janine Cossy; Christophe Poitevin; Domingo Gomez Pardo

doi:10.1055/s-1998-1622

Synlett 1998; 1998(3): 251-252
DOI: 10.1055/s-1998-1622

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Heck Reaction versus Free Radical Reaction for the Synthesis of Spiro[indoline-2,4′-piperidines]

Janine Cossy^* , Christophe Poitevin, Domingo Gomez Pardo

^*Laboratoire de Chimie Organique, Associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France; Fax 33.1.40.79.44.25; E-mail: janine.cossy@espci.fr

Abstract

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Spiro[indoline-2,4′-piperidines] can be prepared from 2-bromoaniline by using a Heck reaction or a free radical reaction as the key step. The radical process produces better yields of spiro[indoline-2,4′-piperidines] than the Heck process.

spiro[indoline-2,4′-piperidines] - Heck reaction - radical - cyclization

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