An Efficient and Facile Synthesis of Novel 3-Benzoyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidines

Ulrich Girreser; Dieter Heber; Martin Schütt

doi:10.1055/s-1998-1625

Synlett 1998; 1998(3): 263-264
DOI: 10.1055/s-1998-1625

letter

© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Efficient and Facile Synthesis of Novel 3-Benzoyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidines

Ulrich Girreser^* , Dieter Heber, Martin Schütt

^*Department of Pharmaceutical Chemistry, University of Kiel, Gutenbergstr. 76, D-24118 Kiel, Germany; Fax +49/04 31/8 80 13 52; E-mail: dheber@pharmazie.uni-kiel.de

Abstract

PDF Download All articles of this category

The condensation of 1-aryl-2-dimethylaminomethylprop-2-en-1-ones 4 with 2-aminopyridines 5 gives rise to the 3-benzoyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidines 3. The reaction is initiated by addition of the pyridine amino group to the enone double bond, followed by deamination and ring closure to give the anellated pyrimidine ring system, which is an excellent precursor for the synthesis of pharmacological active compounds.

1-arylprop-2-en-1-ones - Mannich salts - deamination - pyrido[1,2-a]pyrimidines

PDF (38 kb)