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Synlett 1998; 1998(3): 263-264
DOI: 10.1055/s-1998-1625
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An Efficient and Facile Synthesis of Novel 3-Benzoyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidines

Ulrich Girreser* , Dieter Heber, Martin Schütt
  • *Department of Pharmaceutical Chemistry, University of Kiel, Gutenbergstr. 76, D-24118 Kiel, Germany; Fax +49/04 31/8 80 13 52; E-mail: dheber@pharmazie.uni-kiel.de
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Publication Date:
31 December 2000 (online)

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The condensation of 1-aryl-2-dimethylaminomethylprop-2-en-1-ones 4 with 2-aminopyridines 5 gives rise to the 3-benzoyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidines 3. The reaction is initiated by addition of the pyridine amino group to the enone double bond, followed by deamination and ring closure to give the anellated pyrimidine ring system, which is an excellent precursor for the synthesis of pharmacological active compounds.

1-arylprop-2-en-1-ones - Mannich salts - deamination - pyrido[1,2-a]pyrimidines