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Synlett 1998; 1998(3): 316-318
DOI: 10.1055/s-1998-1631
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Synthesis of Calystegine B2 Analogs by Tandem Tautomerization-Intramolecular Glycosylation of Thioureidosugars

J. M. García Fernández* , C. Ortiz Mellet, J. M. Benito, J. Fuentes
  • *Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, Isla de la Cartuja, E-41092 Sevilla, Spain; Fax 34 5 446 05 65; E-mail: jogarcia@cica.es
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Publication Date:
31 December 2000 (online)

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Ring-modified analogs of calystegine B2, a powerful glycosidase inhibitor of the polyhydroxy-nor-tropane series, have been prepared in one-pot reaction from thiourea-carbohydrate precursors via a tandem tautomerization-intramolecular glycosylation process.

calystegine - thiourea - glycosidase inhibitors - azasugar - iminosugar