Pro-Nucleotides - Recent Advances in the Design of Efficient Tools for the Delivery of Biologically Active Nucleoside Monophosphates

C. Meier

doi:10.1055/s-1998-1637

Synlett 1998; 1998(3): 233-242
DOI: 10.1055/s-1998-1637

new tools in synthesis

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Pro-Nucleotides - Recent Advances in the Design of Efficient Tools for the Delivery of Biologically Active Nucleoside Monophosphates

C. Meier^*

^*Institut für Organische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany; Fax +49-9 31-8 88 46 06; E-mail: meier@chemie.uni-wuerzburg.de

Abstract

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A summary of the most recent advances to the design of pro-nucleotides will be presented. Approaches that have been designed to be activated by enzymes such as carboxyesterases [bis(POM)-, bis(POC)-, bis (SATE)-, bis (AB) phosphotriesters and the arylphosphoramidates] or by reductases [bis(SDTE) approach] will be discussed as well as the amino acids phosporamidate diester concept with its still unknown delivery mechanism and the cycloSal approach that releases the nucleotides by an induced tandem reaction.

pro-nucleotides - antiviral drugs - nucleotide delivery - TK- and ADA-bypass - activation mechanisms

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