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Synlett 1998; 1998(3): 298-300
DOI: 10.1055/s-1998-1648
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Synthetic Study of Pinnatoxin A: Stereoselective Synthesis of the BCD-ring Unit, a Novel 6,5,6-Bis-spiroketal System

Takeshi Noda* , Akihiro Ishiwata, Satoshi Uemura, Satoshi Sakamoto, Masahiro Hirama
  • *Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-77, Japan; Fax +81(22)2 17-65 66; E-mail: hirama@ykbsc.chem.tohoku.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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The bis-spiroketal unit of pinnatoxin A was constructed via a catalytic asymmetric epoxidation and dihydroxylation reaction followed by thermodynamically controlled acetalization.

pinnatoxin A - BCD-ring - bis-spiroketal - Ca2+ channel - equilibrium